Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272028 | 0.87 | PDE10A (0.75) | PDE10AALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7709951 | 0.84 | PDE10A (0.56) | PDE10AMAPTHPGDTSHRPDE4A | |
| SCHEMBL7705002 | 0.84 | PDE10A (0.56) | PDE10AALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7703632 | 0.84 | PDE10A (0.59) | PDE10AMAPTHPGDTSHRPDE4A | |
| SCHEMBL8271910 | 0.79 | PDE10A (0.73) | PDE10AALDH1A1HPGDTSHRPDE4A | |
| SCHEMBL7709755 | 0.79 | PDE10A (0.73) | PDE10AALDH1A1HPGDTSHRPDE4A | |
| SCHEMBL8271493 | 0.78 | PDE10A (0.65) | PDE10AALDH1A1HPGDPDE4APDE4B | |
| SCHEMBL8271482 | 0.78 | PDE10A (0.71) | PDE10AALDH1A1HPGDTSHRPDE4A | |
| SCHEMBL2560664 | 0.77 | PDE10A (0.70) | PDE10AALDH1A1HPGDTSHRPDE4A | |
| SCHEMBL2577947 | 0.76 | PDE10A (0.79) | PDE10ATSHRPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |