Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.77 |
| ▸ | BRD2 | P25440 | 1/20 | 0.77 |
| ▸ | INMT | O95050 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | IDE | P14735 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpyrrolidone SCHEMBL4881818 | 0.92 | BRD4 (0.65) | BRD4BRD2INMTKMT2AMEN1 | |
| Methylpyrrolidone SCHEMBL27843521 | 0.91 | BRD4 (0.77) | BRD4BRD2INMTKMT2AMEN1 | |
| Methylpyrrolidone SCHEMBL1932845 | 0.90 | BRD4 (0.63) | BRD4BRD2INMTKMT2AMEN1 | |
| Methylpyrrolidone SCHEMBL28313707 | 0.89 | BRD4 (0.74) | BRD4BRD2INMTKMT2AMEN1 | |
| Methylpyrrolidone SCHEMBL7705903 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL28121032 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL487 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL1255511 | 0.88 | BRD4 (1.00) | BRD4BRD2INMTKMT2AMEN1 | |
| Methylpyrrolidone SCHEMBL8055062 | 0.88 | BRD4 (1.00) | BRD4BRD2INMTKMT2AMEN1 | |
| Methylpyrrolidone SCHEMBL5423326 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355657-B1 | LOPERAMIDE HYDROCHLORIDE IN PROPYLENE CARBONATE AND ETHANOL | ATRIX LABORATORIES, INC. | 2002-03-12 | — | — | US | disclosed |