Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.59 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271489 | 0.87 | PDE10A (0.63) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL2577993 | 0.86 | PDE10A (0.59) | PDE10AHTTPRKDCALDH1A1KDM4E | |
| SCHEMBL8272011 | 0.86 | PDE10A (0.62) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8271479 | 0.86 | PDE10A (0.66) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8271478 | 0.83 | PDE10A (0.63) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8272031 | 0.83 | PDE10A (0.59) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8271339 | 0.82 | PDE10A (0.59) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8271493 | 0.82 | PDE10A (0.65) | PDE10AHTTALDH1A1KDM4ENPC1 | |
| SCHEMBL8271931 | 0.82 | PDE10A (0.64) | PDE10AALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL8272028 | 0.81 | PDE10A (0.75) | PDE10AALDH1A1KDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |