Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.62 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271479 | 0.90 | PDE10A (0.66) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8271489 | 0.89 | PDE10A (0.63) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL2558017 | 0.88 | PDE10A (0.58) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL7705223 | 0.86 | PDE10A (0.59) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL2556919 | 0.86 | PDE10A (0.51) | PDE10ANPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8271478 | 0.85 | PDE10A (0.63) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8272031 | 0.85 | PDE10A (0.59) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8271339 | 0.85 | PDE10A (0.59) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL8271493 | 0.85 | PDE10A (0.65) | PDE10AMAOANPC1RAB9AKDM4E | |
| SCHEMBL2556902 | 0.84 | PDE10A (0.54) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006011024-A9 | NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD (IN) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006011024-A2 | NEW TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD. (US) | 2006-02-02 | — | — | WO | disclosed |