Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094928 | 0.90 | KDR (0.64) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7702752 | 0.89 | CHEK1 (0.64) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7000769 | 0.89 | CHEK1 (0.64) | KDRCHEK1CDK1CDK2PDGFRB | |
| Water SCHEMBL7089950 | 0.89 | KDR (0.63) | KDRCHEK1CDK1CDK2PDGFRB | |
| Hydrochloric Acid SCHEMBL7089690 | 0.88 | CHEK1 (0.62) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL6994408 | 0.87 | KDR (0.64) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7704724 | 0.86 | CHEK1 (0.60) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7705656 | 0.86 | CHEK1 (0.60) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7094049 | 0.86 | CHEK1 (0.60) | KDRCHEK1CDK1CDK2PDGFRB | |
| SCHEMBL7698415 | 0.86 | CHEK1 (0.60) | KDRCHEK1CDK1CDK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |