Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1697812 | 0.90 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE3BPDE3A | |
| SCHEMBL3305218 | 0.84 | PDE4A (0.45) | PDE4APDE4DALDH1A1 | |
| SCHEMBL18986757 | 0.82 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE3BPDE3A | |
| SCHEMBL30869223 | 0.82 | PDE4A (0.62) | PDE4APDE4BPDE4DPDE3BPDE3A | |
| SCHEMBL1697742 | 0.80 | PDE4A (0.63) | PDE4APDE4BPDE4DPDE3BPDE3A | |
| SCHEMBL3302030 | 0.77 | PDE4A (0.39) | PDE4APDE4DALDH1A1 | |
| SCHEMBL30869217 | 0.75 | PDE4A (0.52) | PDE4APDE4BPDE4DPDE3BPDE3A | |
| SCHEMBL7696542 | 0.75 | PDE4A (0.55) | PDE4APDE4BPDE4DPDE3BPDE3A | |
| SCHEMBL30869219 | 0.74 | KDM4E (0.54) | PDE4APDE4BPDE4DALDH1A1 | |
| SCHEMBL17375277 | 0.74 | KDM4E (0.54) | PDE4APDE4BPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011160632-A1 | BENZODIOXOLE OR BENZODIOXEPINE HETEROCYCLIC COMPOUNDS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-12-29 | — | — | WO | disclosed |