Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6883169 | 0.95 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6883839 | 0.93 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6883426 | 0.81 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6874584 | 0.81 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6884681 | 0.80 | CHRNA7 (0.41) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6880025 | 0.80 | TSHR (0.45) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6882087 | 0.80 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL7062187 | 0.80 | MEN1 (0.44) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6883280 | 0.79 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6881702 | 0.79 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479510-B2 | N-((2S,3R)-2-METHYL-1-AZABICYCLO(2.2.2)OCT-3-YL)-4-(4-HYDROXYP HENOXY)- BENZAMIDE FOR EXAMPLE; TREATING DISEASES OF THE ALPHA-7-NICOTINIC ACETYLCHOLINE RECEPTOR I.E. SCHIZOPHRENIA, OR PSYCHOSIS | PHARMACIA & UPJOHN COMPANY | 2002-11-12 | — | — | US | disclosed |