SCHEMBL7706378

SCHEMBL7706378

CCC1CCCCN1CCn1c(C2CCNC2)nc2c(C(N)=O)cccc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 17/20 0.49
PARP2 Q9UGN5 7/20 0.40
PARP3 Q9Y6F1 3/20 0.39
TNKS O95271 1/20 0.39
CHRM2 P08172 1/20 0.39
CHRM1 P11229 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
ADRA1A P35348 1/20 0.39
SLC6A3 Q01959 1/20 0.39
KCNH2 Q12809 1/20 0.39
DYRK1A Q13627 1/20 0.39
PARP15 Q460N3 1/20 0.39
PARP14 Q460N5 1/20 0.39
PARP10 Q53GL7 1/20 0.39
PARP12 Q9H0J9 1/20 0.39
TNKS2 Q9H2K2 1/20 0.39
PARP4 Q9UKK3 1/20 0.39
DYRK1B Q9Y463 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5621642 0.96 PARP1 (0.48) PARP1PARP2PARP3TNKSCHRM2
SCHEMBL5621352 0.95 PARP1 (0.52) PARP1PARP2JAK2JAK1TYK2
SCHEMBL7043890 0.88 PARP1 (0.35) PARP1CHRM1JAK2JAK1TYK2
SCHEMBL5619904 0.86 PARP1 (0.67) PARP1PARP2JAK2JAK1TYK2
SCHEMBL5620873 0.86 PARP1 (0.55) PARP1PARP2PARP3TNKSCHRM2
SCHEMBL5620585 0.85 PARP1 (0.47) PARP1PARP2PARP3DYRK1A
SCHEMBL5622515 0.85 PARP1 (0.61) PARP1PARP2
SCHEMBL7705631 0.85 PARP1 (0.47) PARP1PARP2PARP3DYRK1A
SCHEMBL5621294 0.85 PARP1 (0.54) PARP1PARP2PARP3TNKSCHRM2
SCHEMBL5621375 0.84 PARP1 (0.57) PARP1PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6448271-B1 SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY BASF AKTIENGESELLSCHAFT (DE) 2002-09-10 US disclosed