Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 7/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620585 | 0.98 | PARP1 (0.47) | PARP1PARP2PARP3MAP4K4CSF1R | |
| SCHEMBL7700402 | 0.91 | PARP1 (0.49) | PARP1PARP2PARP3 | |
| SCHEMBL7041448 | 0.88 | TAAR1 (0.36) | PARP1TAAR1 | |
| SCHEMBL5621352 | 0.87 | PARP1 (0.52) | PARP1PARP2 | |
| SCHEMBL5621642 | 0.86 | PARP1 (0.48) | PARP1PARP2PARP3MAP4K4CSF1R | |
| SCHEMBL7706378 | 0.85 | PARP1 (0.49) | PARP1PARP2PARP3DYRK1A | |
| SCHEMBL5619993 | 0.85 | PARP1 (0.53) | PARP1PARP2PARP3PIM1AURKB | |
| SCHEMBL5621834 | 0.85 | PARP1 (0.52) | PARP1PARP2PARP3 | |
| SCHEMBL5620530 | 0.84 | PARP1 (0.57) | PARP1PARP2 | |
| SCHEMBL7705473 | 0.83 | PARP1 (0.56) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448271-B1 | SUCH AS 2-(PIPERIDIN-4-YL)BENZIMIDAZOLE-4-CARBOXAMIDE; INHIBITORS OF ENZYME POLY(ADP-RIBOSE)POLYMERASE; IMPROVED WATER SOLUBILITY | BASF AKTIENGESELLSCHAFT (DE) | 2002-09-10 | — | — | US | disclosed |