Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | MST1R | Q04912 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 12/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | ROS1 | P08922 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591611 | 0.88 | HDAC4 (0.39) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2593048 | 0.77 | KDR (0.36) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2593301 | 0.74 | KDR (0.35) | CLK4ROCK1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2583621 | 0.74 | HDAC4 (0.37) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2588932 | 0.74 | KDR (0.36) | CLK4ROCK1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL2583911 | 0.73 | KDR (0.34) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2588602 | 0.72 | CLK4 (0.40) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2595302 | 0.72 | HDAC4 (0.41) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2588342 | 0.72 | KDR (0.33) | CLK4ROCK1CDK5DYRK1APIK3CD | |
| SCHEMBL2591838 | 0.72 | HDAC4 (0.37) | CLK4ROCK1CDK5DYRK1APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |