SCHEMBL7706934

SCHEMBL7706934

CCOCc1cccc2cc(C(N)=O)oc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.57
ALDH1A1 P00352 2/20 0.57
LMNA P02545 1/20 0.42
RECQL P46063 1/20 0.42
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 2/20 0.41
HSD17B10 Q99714 3/20 0.40
KDM4E B2RXH2 1/20 0.40
PARP1 P09874 1/20 0.39
AKR1C1 Q04828 1/20 0.39
RAB9A P51151 4/20 0.39
NPC1 O15118 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
MEN1 O00255 2/20 0.39
ADORA2A P29274 1/20 0.38
ADORA2B P29275 1/20 0.38
ADORA1 P30542 1/20 0.38
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7703462 0.86 ALDH1A1 (0.41) KMT2AALDH1A1LMNARECQLCYP1A2
Hydrochloric Acid SCHEMBL7706870 0.85 KMT2A (0.40) KMT2AALDH1A1LMNARECQLCYP1A2
SCHEMBL7706290 0.85 KDM4E (0.50) KMT2AALDH1A1LMNARECQLCYP1A2
SCHEMBL7701266 0.84 KMT2A (0.39) KMT2AALDH1A1LMNARECQLCYP1A2
Hydrochloric Acid SCHEMBL7701264 0.83 KMT2A (0.39) KMT2AALDH1A1LMNARECQLCYP1A2
SCHEMBL7709279 0.78 KMT2A (0.72) KMT2AALDH1A1LMNARECQLCYP1A2
SCHEMBL2681830 0.73 ALDH1A1 (0.65) KMT2AALDH1A1LMNARECQLRAB9A
SCHEMBL10509414 0.73 ALDH1A1 (0.64) KMT2AALDH1A1LMNARECQLRAB9A
SCHEMBL4745478 0.73 KMT2A (1.00) KMT2AALDH1A1LMNARECQLHSD17B10
SCHEMBL30367973 0.71 ALDH1A1 (0.62) KMT2AALDH1A1LMNARECQLCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100347164-C Benzofuryl derivatives and their use HOFMMANN LA ROCHE AG F (CH) 2007-11-07 CN disclosed
EP-0906301-B1 BENZOFURYL DERIVATIVES AND THEIR USE HOFFMANN LA ROCHE (CH) 2002-10-02 EP disclosed
US-5955495-A BENZOFURAN-2-CARBOXAMIDINE OR 2-CARBOXAMIDOXIME COMPOUNDS USEFUL IN THE CONTROL OR PREVENTION OF ILLNESSES OR DISORDERS OF THE CENTRAL NERVOUS SYSTEM SUCH AS MIGRAINE, SCHIZOPHRENIA, ANXIETY STATES, SLEEP DISORDERS, ANOREXIA, ALZHEIMER'S HOFFMANN-LA ROCHE INC. (US) 1999-09-21 US disclosed
CN-1217720-A Benzofuryl derivatives and their use HOFMMANN LA ROCHE (CH) 1999-05-26 CN disclosed
EP-0906301-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1999-04-07 EP disclosed
WO-1997042183-A1 BENZOFURYL DERIVATIVES AND THEIR USE F. HOFFMANN-LA ROCHE AG (CH) 1997-11-13 WO disclosed