Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | LYN | P07948 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.38 |
| ▸ | TNF | P01375 | 5/20 | 0.38 |
| ▸ | HCK | P08631 | 5/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | MUSK | O15146 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297067 | 0.85 | MAPK14 (0.55) | MAPK14ABL1RAF1LYNSRC | |
| SCHEMBL6411778 | 0.79 | MAPK14 (0.41) | MAPK14ABL1RAF1LYNSRC | |
| SCHEMBL6574700 | 0.77 | MAPK14 (0.36) | MAPK14ABL1RAF1LYNSRC | |
| SCHEMBL14459367 | 0.77 | GCK (0.33) | MAPK14 | |
| SCHEMBL14459299 | 0.76 | GCK (0.37) | — | |
| SCHEMBL5618849 | 0.76 | MAPK14 (0.38) | MAPK14ABL1RAF1LYNMAPK9 | |
| SCHEMBL5619598 | 0.75 | GSK3A (0.41) | MAPK14ABL1RAF1LYNSRC | |
| SCHEMBL6165074 | 0.74 | MAPK14 (0.44) | MAPK14RAF1 | |
| SCHEMBL7677125 | 0.74 | MAPK14 (0.52) | MAPK14ABL1RAF1LYNSRC | |
| SCHEMBL6163971 | 0.73 | MAPK14 (0.51) | MAPK14RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372773-B1 | TREATMENT OF INFLAMMATION, ARTHRITIS WITH UREA OR THIOUREA HETEROCYCLES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-04-16 | — | — | US | disclosed |