Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707366 | 0.82 | CYP19A1 (0.45) | CYP19A1CYP11B1CYP11B2PDE4BHTT | |
| SCHEMBL5018006 | 0.79 | CYP19A1 (0.49) | CYP19A1CYP11B1CYP11B2KDM4EPDE4B | |
| SCHEMBL8272708 | 0.76 | CYP19A1 (0.42) | CYP19A1CYP11B1CYP11B2ALDH1A1MAPT | |
| SCHEMBL5022607 | 0.74 | CYP19A1 (0.48) | CYP19A1CYP11B1CYP11B2PDE4BKMT2A | |
| SCHEMBL8298197 | 0.72 | CYP19A1 (0.47) | CYP19A1CYP11B1CYP11B2HSD17B10PDE4B | |
| SCHEMBL8271921 | 0.72 | GAA (0.44) | CYP19A1CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL5016456 | 0.71 | PDE4B (0.51) | CYP19A1CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL7328799 | 0.69 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5023416 | 0.68 | CYP19A1 (0.50) | CYP19A1CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL5025269 | 0.67 | PDE4D (0.43) | CYP19A1CYP11B1CYP11B2PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |