Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.57 |
| ▸ | PDE4A | P27815 | 5/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326891 | 0.81 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7438760 | 0.81 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7326887 | 0.81 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7441216 | 0.81 | PDE4B (0.65) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7440781 | 0.81 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7441213 | 0.81 | PDE4B (0.65) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7417861 | 0.81 | NFE2L2 (0.61) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7419336 | 0.81 | NFE2L2 (0.61) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7301099 | 0.80 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7332000 | 0.80 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |