Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 18/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 15/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707797 | 0.85 | ADRA1A (0.43) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7707793 | 0.83 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7702064 | 0.81 | ADRA1A (0.47) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7704704 | 0.67 | KMT2A (0.42) | — | |
| SCHEMBL7707876 | 0.63 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL7702045 | 0.62 | ADRA1A (0.40) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL2310528 | 0.60 | GSK3B (0.42) | — | |
| SCHEMBL2307655 | 0.60 | SCN9A (0.57) | — | |
| SCHEMBL2308969 | 0.59 | SCN9A (0.57) | EDNRBEDNRA | |
| SCHEMBL7932825 | 0.59 | ADRA1A (1.00) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358959-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-03-19 | — | — | US | disclosed |