Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712028 | 1.00 | CHRM2 (0.39) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL16857486 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL8262943 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL30680499 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL30680515 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL24739167 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL15632175 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL15632464 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL14371725 | 0.83 | NR1H2 (0.40) | CHRM2CHRM1CHRM3NR1H2HSD11B1 | |
| SCHEMBL21466110 | 0.83 | NR1H2 (0.36) | CHRM2CHRM1CHRM3NR1H2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372914-B1 | Intermediates useful for the manufacture of carbapenem and a stereoselective manufacturing method therefor | EISAI CO., LTD. (JP) | 2002-04-16 | — | — | US | disclosed |
| US-6218550-B1 | MANUFACTURING (2S,4S)-2-(((R)-HYDROXY-(3R)-CYCLIC AMINE-3-YL)METHYL)PYRROLIDINE-4-THIOL OR A SALT THEREOF | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| EP-0545290-B1 | Aminoalkylpyrrolidinylthiocarbapenem derivatives | BANYU PHARMA CO LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| EP-1020440-A1 | INTERMEDIATES USEFUL IN PRODUCING CARBAPENEM AND PROCESS FOR THE STEREOSELECTIVE PRODUCTION OF THE SAME | Eisai Co., Ltd. (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-5550121-A | ANTIBIOTICS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| WO-1993011128-A1 | AMINOALKYLPYRROLIDINYLTHIOCARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-06-10 | — | — | WO | disclosed |
| EP-0545290-A1 | Aminoalkylpyrrolidinylthiocarbapenem derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |