Butane

Butane

SCHEMBL7708050

CCCC.I.N.c1ccc(CCc2ccccc2)cc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG

The experimentally established mechanism targets of Butane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 known ✓ P11229 1/20 0.46
TP53 P04637 1/20 0.52
MAOA P21397 2/20 0.50
MAOB P27338 2/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
ALOX15 P16050 1/20 0.50
ALOX12 P18054 1/20 0.50
CASP1 P29466 1/20 0.50
HSD17B10 Q99714 1/20 0.50
SIGMAR1 Q99720 2/20 0.48
KCNH2 Q12809 3/20 0.48
TAAR1 Q96RJ0 3/20 0.48
ATM Q13315 1/20 0.48
TDP1 Q9NUW8 2/20 0.48
CYP2A6 P11509 1/20 0.48
HTR2A P28223 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
LOXL2 Q9Y4K0 1/20 0.48
CHRM2 P08172 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butane SCHEMBL6866259 0.94 TP53 (0.58) TP53MAOAMAOBALDH1A1HPGD
Butane SCHEMBL11798210 0.92 TP53 (0.55) TP53MAOAMAOBALDH1A1HPGD
Ammonia Solution, Strong SCHEMBL479482 0.86 TP53 (0.55) TP53ALDH1A1HPGDALOX15ALOX12
Iodide SCHEMBL28827008 0.86 TP53 (0.55) TP53ALDH1A1HPGDALOX15ALOX12
Iodide SCHEMBL10910035 0.86 TP53 (0.55) TP53ALDH1A1HPGDALOX15ALOX12
Ammonia Solution, Strong SCHEMBL5761625 0.85 ALDH1A1 (0.65) MAOAMAOBALDH1A1HPGDALOX15
Iodide SCHEMBL9705905 0.85 ALDH1A1 (0.65) MAOAMAOBALDH1A1HPGDALOX15
Ammonia Solution, Strong SCHEMBL439977 0.85 ALDH1A1 (0.65) MAOAMAOBALDH1A1HPGDALOX15
Ammonia Solution, Strong SCHEMBL3183291 0.84 TP53 (0.48) TP53MAOAMAOBALDH1A1HPGD
Hydrochloric Acid SCHEMBL8986132 0.83 TP53 (0.52) TP53MAOAMAOBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6359080-B1 FOR OUTDOOR DURABLE COATINGS RESOLUTION PERFORMANCE PRODUCTS LLC 2002-03-19 US disclosed
CN-1330694-A Epoxy functional polyester resins having increased molecular weight, process for their preparation and outdoor durable coating compositions comprising them SHELL INT RESEARCH (NL) 2002-01-09 CN disclosed
EP-1151046-A1 EPOXY FUNCTIONAL POLYESTER RESINS HAVING AN INCREASED MOLECULAR WEIGHT, PROCESS FOR THEIR PREPARATION, AND OUTDOOR DURABLE COATING COMPOSITIONS COMPRISING THEM SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 2001-11-07 EP disclosed
US-6103835-A FOR OUTDOOR DURABLE POWDER COATING COMPOSITIONS SHELL OIL COMPANY (US) 2000-08-15 US disclosed
WO-2000027937-A1 EPOXY FUNCTIONAL POLYESTER RESINS HAVING AN INCREASED MOLECULAR WEIGHT, PROCESS FOR THEIR PREPARATION, AND OUTDOOR DURABLE COATING COMPOSITIONS COMPRISING THEM SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 2000-05-18 WO disclosed