Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.49 |
| ▸ | FNTB | P49356 | 13/20 | 0.49 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708788 | 1.00 | FNTA (0.49) | FNTAFNTBPGGT1BALDH1A1NPSR1 | |
| SCHEMBL7671901 | 0.87 | FNTA (0.51) | FNTAFNTBPGGT1BALDH1A1NPSR1 | |
| SCHEMBL7672400 | 0.87 | FNTA (0.51) | FNTAFNTBPGGT1BALDH1A1NPSR1 | |
| SCHEMBL7671904 | 0.87 | FNTA (0.51) | FNTAFNTBPGGT1BALDH1A1NPSR1 | |
| SCHEMBL8617653 | 0.86 | FNTA (0.45) | FNTAFNTBALDH1A1NPSR1 | |
| SCHEMBL7703375 | 0.86 | FNTA (0.45) | FNTAFNTBALDH1A1NPSR1 | |
| SCHEMBL8617640 | 0.86 | FNTA (0.45) | FNTAFNTBALDH1A1NPSR1 | |
| SCHEMBL7703378 | 0.86 | FNTA (0.45) | FNTAFNTBALDH1A1NPSR1 | |
| SCHEMBL7703301 | 0.86 | FNTA (0.52) | FNTAFNTB | |
| SCHEMBL7703293 | 0.86 | FNTA (0.52) | FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | claimed |
| US-6414145-B1 | TREATING CANCER AND NEUROFIBROMATOSIS | ZENECA LIMITED (GB) | 2002-07-02 | — | — | US | disclosed |
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |