Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | APP | P05067 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | BLVRB | P30043 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708973 | 1.00 | MEN1 (0.66) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL5830402 | 0.93 | CA12 (0.65) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL10528243 | 0.90 | CA12 (0.67) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL18270511 | 0.88 | CA1 (0.54) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL7708868 | 0.87 | MEN1 (0.51) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL7708870 | 0.87 | MEN1 (0.51) | MEN1KMT2ATDP1APPTHRB | |
| Potassium Ion SCHEMBL11747963 | 0.83 | PTGS2 (0.56) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL11745347 | 0.83 | PTGS2 (0.56) | MEN1KMT2ATDP1APPTHRB | |
| SCHEMBL11747967 | 0.83 | PHLPP2 (0.62) | MEN1KMT2ATDP1APPTHRB | |
| Potassium Ion SCHEMBL11747949 | 0.83 | PTGS2 (0.56) | MEN1KMT2ATDP1APPTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417178-B1 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits | UNIVERSITY OF PITTSBURGH | 2002-07-09 | — | — | US | disclosed |
| EP-1110945-A2 | Azocompounds for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | UNIVERSITY OF PITTSBURGH (US) | 2001-06-27 | — | — | EP | disclosed |
| US-6168776-B1 | Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition | UNIVERSITY OF PITTSBURGH | 2001-01-02 | — | — | US | disclosed |
| US-6133259-A | DIAGNOSIS OF ALZHEIMER'S DISEASE | UNIVERSITY OF PITTSBURGH (US) | 2000-10-17 | — | — | US | disclosed |
| US-6114175-A | AMYLOID-BINDING COMPOUNDS WHICH ARE NON-AZO DERIVATIVES OF CHRYSAMINE G TO DETERMINE DEGREE OF BRAIN DEPOSITS QUANTITATIVELY CHARACTERIZED BY AMYLOIDOSIS; DOWN'S SYNDROME; PREVENT CELL DEGENERATION; RADIOACTIVE IMAGING | UNIVERSITY OF PITTSBURGH (US) | 2000-09-05 | — | — | US | disclosed |