Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872550 | 0.85 | LMNA (0.61) | LMNASMN1; SMN2POLBHPGDUSP2 | |
| SCHEMBL22530321 | 0.83 | LMNA (0.58) | LMNASMN1; SMN2POLBATMHPGD | |
| SCHEMBL2644386 | 0.81 | SMN1; SMN2 (0.69) | LMNASMN1; SMN2USP2TP53TRPM8 | |
| SCHEMBL2619292 | 0.80 | SMN1; SMN2 (0.68) | LMNASMN1; SMN2ATMHPGDCYP1A2 | |
| SCHEMBL3087490 | 0.79 | LMNA (0.54) | LMNASMN1; SMN2POLBATMHPGD | |
| SCHEMBL3544012 | 0.79 | LMNA (0.71) | LMNASMN1; SMN2HPGDCYP2C9TSHR | |
| SCHEMBL2187784 | 0.77 | LMNA (0.69) | LMNASMN1; SMN2TP53TRPM8NPC1 | |
| SCHEMBL8849222 | 0.77 | HDAC6 (0.60) | LMNASMN1; SMN2POLBATMTP53 | |
| SCHEMBL10732701 | 0.77 | LMNA (0.52) | LMNASMN1; SMN2POLBATMHPGD | |
| SCHEMBL7061698 | 0.77 | LMNA (0.63) | LMNASMN1; SMN2HPGDTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436952-B1 | CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS; INFLAMMATORY AIRWAY DISORDERS, SUCH AS ASTHMA; ANTIINFLAMMATORY; 6-(4-(2H-2-ETHYLTETRAZOL-5-YL) PHENYL)-1,2,3,4,4A,10B-HEXAHYDROBENZO(C)(1,6)NAOHTHYRIDINE N-2-OXIDES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2002-08-20 | — | — | US | disclosed |