Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 19/20 | 0.46 |
| ▸ | RXRG | P48443 | 9/20 | 0.38 |
| ▸ | RXRB | P28702 | 8/20 | 0.38 |
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 3/20 | 0.38 |
| ▸ | RARG | P13631 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713197 | 0.80 | RXRA (0.41) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7217727 | 0.79 | RXRA (0.54) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7713132 | 0.78 | RXRA (0.42) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7715180 | 0.74 | RXRA (0.41) | RXRARXRGRXRBRARARARB | |
| SCHEMBL6157083 | 0.73 | RXRA (0.52) | RXRARXRGRXRBRARARARB | |
| SCHEMBL6157965 | 0.73 | RXRA (0.52) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8639015 | 0.73 | RXRA (0.41) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8681617 | 0.72 | RXRA (0.40) | RXRARXRGRXRBRARARARB | |
| SCHEMBL5537842 | 0.71 | RXRA (0.53) | RXRARXRGRXRBRARARARB | |
| SCHEMBL7622765 | 0.71 | RXRA (0.48) | RXRARXRGRXRBRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6368608-B1 | SKIN DISORDERS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) (FR) | 2002-04-09 | — | — | US | disclosed |
| US-6162445-A | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-19 | — | — | US | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |