Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | NPC1L1 | Q9UHC9 | 8/20 | 0.58 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7706313 | 0.99 | OPRL1 (0.60) | OPRL1OPRM1OPRK1MEN1CYP3A4 | |
| SCHEMBL5095284 | 0.89 | OPRL1 (0.72) | OPRL1OPRM1OPRK1MEN1CYP3A4 | |
| SCHEMBL5095281 | 0.89 | OPRL1 (0.72) | OPRL1OPRM1OPRK1MEN1CYP3A4 | |
| SCHEMBL12315495 | 0.86 | OPRL1 (0.65) | OPRL1OPRM1OPRK1MEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7706375 | 0.86 | BDKRB2 (0.54) | OPRL1OPRM1OPRK1NPC1L1BDKRB2 | |
| Hydrochloric Acid SCHEMBL7703822 | 0.85 | BDKRB2 (0.54) | OPRL1OPRM1OPRK1NPC1L1BDKRB2 | |
| Hydrochloric Acid SCHEMBL7706297 | 0.84 | NPC1L1 (0.59) | OPRL1OPRM1OPRK1NPC1L1BDKRB2 | |
| SCHEMBL14013754 | 0.84 | OPRL1 (0.61) | OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL20187031 | 0.83 | OPRL1 (0.67) | OPRL1OPRM1OPRK1MEN1CYP3A4 | |
| Hydrochloric Acid SCHEMBL7705553 | 0.83 | OPRL1 (0.60) | OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921125-B1 | 1,3,8-Triazaspiro[4,5]decan-4-on derivatives | HOFFMANN LA ROCHE (CH) | 2002-01-30 | — | — | EP | disclosed |
| US-6043366-A | USEFUL IN TREATING DISORDERS INVOLVING THE ORPHANIN FQ(A SEVENTEEN AMINO ACID LONG PEPTIDE) RECEPTOR. | HOFFMAN-LA ROCHE INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0921125-A1 | 1,3,8-Triaza-spiro 4,5 decan-4-on derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |