Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 7/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.48 |
| ▸ | FEN1 | P39748 | 2/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | XBP1 | P17861 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709641 | 1.00 | MAPT (0.48) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7706407 | 0.85 | MAPT (0.51) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7706719 | 0.76 | MAPT (0.54) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7709699 | 0.75 | MAPT (0.50) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7709801 | 0.73 | HEXA (0.40) | MAPTPOLBCYP1A2TDP1KMT2A | |
| SCHEMBL10832427 | 0.72 | KMT2A (0.50) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7709580 | 0.71 | KMT2A (0.68) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7703818 | 0.69 | MAPT (0.60) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7706682 | 0.68 | MAPT (0.69) | MAPTPOLBERCC1FEN1ERCC4 | |
| SCHEMBL7709613 | 0.67 | HDAC3 (0.55) | MAPTPOLBERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |
| EP-0939754-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998019648-A2 | N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |