Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.54 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561770 | 0.92 | ALOX5 (0.52) | ALOX5PDE10ACXCR3PDK1 | |
| SCHEMBL2566006 | 0.92 | PDE10A (0.61) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2566267 | 0.92 | ALOX5 (0.59) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2567411 | 0.91 | ALOX5 (0.57) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2562668 | 0.91 | PDE10A (0.59) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2566025 | 0.89 | ALOX5 (0.57) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2566521 | 0.86 | PDE10A (0.51) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2572865 | 0.85 | PDE10A (0.55) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL7716900 | 0.85 | PDE10A (0.53) | ALOX5PDE10APDK1FFAR1AKR1B1 | |
| SCHEMBL2566793 | 0.85 | PDE10A (0.53) | ALOX5PDE10APDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |