Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26650858 | 0.96 | TSHR (0.52) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL18771044 | 0.92 | TSHR (0.52) | TSHRLMNAALDH1A1KMT2ARECQL | |
| SCHEMBL26650804 | 0.92 | TSHR (0.52) | TSHRLMNAALDH1A1KMT2ARECQL | |
| SCHEMBL10608277 | 0.92 | TSHR (0.46) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9105726 | 0.92 | TSHR (0.61) | TSHRLMNAALDH1A1KMT2ARECQL | |
| SCHEMBL11949551 | 0.90 | TSHR (0.64) | TSHRLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL816422 | 0.88 | TSHR (0.67) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1277943 | 0.88 | TSHR (0.67) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1199597 | 0.88 | TSHR (0.67) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1886420 | 0.88 | TSHR (0.67) | TSHRLMNAALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362352-B1 | MEDICAL DIAGNOSIS | DUKE UNIVERSITY | 2002-03-26 | — | — | US | disclosed |
| WO-2000063216-A1 | F-18-LABELED THIA FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2000-10-26 | — | — | WO | disclosed |