SCHEMBL7712178

SCHEMBL7712178

O=C1OC(=O)c2cc([N+](=O)[O-])c(Cl)c3cc([N+](=O)[O-])cc1c23

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.47
GPR35 Q9HC97 2/20 0.37
KDM1A O60341 1/20 0.36
TSHR P16473 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
TYMS P04818 4/20 0.36
CYP3A4 P08684 2/20 0.35
HIF1A Q16665 2/20 0.35
HPGD P15428 2/20 0.35
ALOX15 P16050 1/20 0.35
TXNRD1 Q16881 1/20 0.35
TXNRD3 Q86VQ6 1/20 0.35
TXNRD2 Q9NNW7 1/20 0.35
VCAM1 P19320 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
TP53 P04637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709521 0.87 ALDH1A1 (0.49) ALDH1A1GPR35KDM1ATSHRTDP1
SCHEMBL7709612 0.82 TYMS (0.51) ALDH1A1TDP1TYMSCYP3A4HIF1A
SCHEMBL7709442 0.82 ALDH1A1 (0.47) ALDH1A1GPR35TDP1TYMSHIF1A
SCHEMBL5142990 0.81 ALDH1A1 (0.57) ALDH1A1TSHRTDP1TYMSCYP3A4
SCHEMBL7709389 0.79 TYMS (0.55) ALDH1A1TDP1TYMSCYP3A4HIF1A
SCHEMBL7708955 0.76 ALDH1A1 (0.47) ALDH1A1TDP1MEN1KMT2ACYP1A2
SCHEMBL3276659 0.74 ALDH1A1 (0.59) ALDH1A1TSHRTDP1TYMSMEN1
SCHEMBL9077637 0.73 ALDH1A1 (0.51) ALDH1A1TSHRTDP1TYMSCYP3A4
SCHEMBL11669000 0.73 TYMS (0.46) ALDH1A1GPR35TSHRTDP1TYMS
SCHEMBL30631737 0.71 ALDH1A1 (0.56) ALDH1A1GPR35TSHRTDP1TYMS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6362181-B1 BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS WARNER-LAMBERT COMPANY 2002-03-26 US disclosed
US-6177423-B1 N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS WARNER-LAMBERT COMPANY 2001-01-23 US disclosed
EP-0939754-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1999-09-08 EP disclosed
WO-1998019648-A2 N-OXY-NAPHTHALIMIDES AS ANTIBACTERIAL AGENTS WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed