Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SI | P14410 | 2/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591201 | 0.88 | MGAM (0.43) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL2585698 | 0.78 | GSK3B (0.42) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL14737126 | 0.77 | POLQ (0.39) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL7712508 | 0.77 | MAPKAPK2 (0.38) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL2593088 | 0.76 | GSK3B (0.41) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL14737558 | 0.75 | POLQ (0.37) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL14736569 | 0.75 | POLQ (0.37) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL26029646 | 0.75 | TDP1 (0.43) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL7713989 | 0.74 | POLQ (0.37) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 | |
| SCHEMBL2589137 | 0.74 | GSK3B (0.40) | GSK3BMAPKAPK2DAPK3NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |