Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | TARS1 | P26639 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 3/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592812 | 0.90 | CA1 (0.41) | MAPKAPK2CA1CA2CA9CA12 | |
| SCHEMBL2594294 | 0.85 | AKT1 (0.36) | MAPKAPK2CA1CA2CA9CA12 | |
| SCHEMBL2588115 | 0.81 | PTGS2 (0.39) | MAPKAPK2DAPK3NTRK1PIM1FLT3 | |
| SCHEMBL2593103 | 0.80 | TARS1 (0.40) | MAPKAPK2CA1CA2CA9CA12 | |
| SCHEMBL2584393 | 0.77 | PDE4A (0.37) | MAPKAPK2DAPK3NTRK1PIM1FLT3 | |
| SCHEMBL7712835 | 0.77 | GSK3B (0.40) | MAPKAPK2DAPK3NTRK1PIM1FLT3 | |
| SCHEMBL2588546 | 0.75 | PRF1 (0.51) | MAPKAPK2DAPK3NTRK1PIM1FLT3 | |
| SCHEMBL7711917 | 0.75 | MAOA (0.45) | PTGS2PTGS1 | |
| SCHEMBL2584262 | 0.73 | SLC6A4 (0.42) | MAPKAPK2DAPK3NTRK1PIM1FLT3 | |
| SCHEMBL14737565 | 0.73 | MAOA (0.45) | CA1CA2CA9CA12PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |