Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.49 |
| ▸ | MAOA | P21397 | 7/20 | 0.43 |
| ▸ | MAOB | P27338 | 7/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085122 | 0.80 | GRM5 (0.38) | GRM5GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL14979694 | 0.79 | GRM5 (0.47) | GRM5MAOAMAOBCYP2A6GABRA1 | |
| SCHEMBL7085730 | 0.78 | GRM5 (0.62) | GRM5GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8607160 | 0.76 | MAOB (0.48) | GRM5MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL29649358 | 0.76 | MAOB (0.62) | GRM5MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL4219924 | 0.76 | MAOB (0.62) | GRM5MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL6239982 | 0.75 | RARB (0.39) | GRM5GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL6596693 | 0.75 | GRM5 (0.52) | GRM5MAOAMAOBGABRA1GABRG2 | |
| SCHEMBL6235870 | 0.74 | VHL (0.51) | GRM5GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL7535201 | 0.74 | GRM5 (0.47) | GRM5MAOAMAOBCYP2A6PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369100-B1 | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids | ALLERGAN SALES, INC. | 2002-04-09 | — | — | US | disclosed |
| US-6025388-A | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids | ALLERGAN SALES, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0828490-A1 | RAR-beta SELECTIVE RETINOID COMPOUNDS FOR INHIBITING GENE EXPRESSION PROMOTED BY AP1 PROTEIN AND THEIR USE IN THERAPY | Allergan (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996033716-A1 | RARβ SELECTIVE RETINOID COMPOUNDS FOR INHIBITING GENE EXPRESSION PROMOTED BY AP1 PROTEIN AND THEIR USE IN THERAPY | ALLERGAN (US) | 1996-10-31 | — | — | WO | disclosed |