Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | MAOA | P21397 | 8/20 | 0.44 |
| ▸ | MAOB | P27338 | 8/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30832140 | 0.76 | SLC6A4 (0.40) | HRH3CRHBPCRHR2 | |
| SCHEMBL4728829 | 0.74 | GRM5 (0.47) | GRM5HRH3CRHBPCRHR2 | |
| SCHEMBL7712895 | 0.74 | GRM5 (0.49) | GRM5MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL29649358 | 0.73 | MAOB (0.62) | GRM5MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL4219924 | 0.73 | MAOB (0.62) | GRM5MAOAMAOBCYP2A6PRKCI | |
| SCHEMBL8607160 | 0.73 | MAOB (0.48) | GRM5MAOAMAOBHRH3CYP2A6 | |
| SCHEMBL1344667 | 0.71 | MAOA (0.49) | MAOAMAOBCYP2A6PRKCIPBRM1 | |
| SCHEMBL23795040 | 0.71 | MAOB (0.62) | MAOAMAOBHRH3 | |
| SCHEMBL16471647 | 0.69 | MAOB (0.59) | MAOAMAOBHRH3 | |
| SCHEMBL9672085 | 0.68 | HRH3 (0.49) | HRH3MEN1KMT2ACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931086-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2002-05-02 | — | — | EP | disclosed |
| US-6133240-A | INHIBITION OF SELECTINS, AND THUS OF CELL ADHESION | DARWIN DISCOVERY, LTD. (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0931086-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-07-28 | — | — | EP | disclosed |
| WO-1998009977-A1 | TETRAHYDRONAPTHALENE DERIVATIVES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-03-12 | — | — | WO | disclosed |