Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 12/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 3/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.33 |
| ▸ | BIRC8 | Q96P09 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14170536 | 0.83 | ALDH1A1 (0.35) | XIAPMAPK1ACEBIRC2BIRC3 | |
| SCHEMBL14170527 | 0.81 | ALDH1A1 (0.34) | XIAPMAPK1BIRC2BIRC3BIRC8 | |
| SCHEMBL14170525 | 0.80 | BIRC2 (0.35) | XIAPMAPK1BIRC2BIRC3BIRC8 | |
| SCHEMBL14170535 | 0.80 | BIRC2 (0.35) | XIAPMAPK1BIRC2BIRC3BIRC8 | |
| SCHEMBL14170548 | 0.79 | ALDH1A1 (0.35) | XIAPBIRC2BIRC3BIRC8 | |
| SCHEMBL7711644 | 0.78 | ACE (0.53) | XIAPACEBIRC2BIRC3BIRC8 | |
| SCHEMBL10331830 | 0.77 | XIAP (0.42) | XIAPACEBIRC2BIRC3BIRC8 | |
| SCHEMBL10331851 | 0.76 | XIAP (0.47) | XIAPBIRC2BIRC3BIRC8 | |
| SCHEMBL10331804 | 0.76 | XIAP (0.47) | XIAPBIRC2BIRC3BIRC8 | |
| SCHEMBL14169821 | 0.75 | MAPK1 (0.36) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509330-B2 | Angiotensin converting enzyme (ACE); neutral endopeptidase (NEP); containing a dipeptide derived from an amino acid, or a conformationally restricted dipeptide mimic | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | disclosed |