Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18831734 | 0.83 | CA1 (0.41) | APPCA1CA2CA7CA9 | |
| SCHEMBL2539698 | 0.79 | CA1 (0.57) | APPCA1CA2CA7CA9 | |
| SCHEMBL5270439 | 0.78 | SMN1; SMN2 (0.47) | APPCA1CA2CA7CA9 | |
| SCHEMBL146841 | 0.78 | CA1 (0.61) | CA1CA2CA7CA9CA12 | |
| SCHEMBL5642052 | 0.78 | MAPT (0.55) | APPCA2MAPTKDM4EGAA | |
| SCHEMBL6192249 | 0.77 | KMT2A (0.47) | KDM4ELMNAALDH1A1TP53HPGD | |
| Hydrochloric Acid SCHEMBL2862732 | 0.77 | CA1 (0.55) | APPCA1CA2CA7CA9 | |
| SCHEMBL24656097 | 0.77 | APP (0.43) | APPCA1CA2CA7CA9 | |
| SCHEMBL15362255 | 0.77 | IDO1 (0.48) | APPCA1CA2CA7CA9 | |
| SCHEMBL8146985 | 0.76 | CA1 (0.43) | CA1CA2CA7CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130253185-A1 | NOVEL CATALYSTS | DALHOUSIE UNIVERSITY (CA) | 2013-09-26 | — | — | US | disclosed |
| WO-2011124524-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4 INHIBITORS AND EP4 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-10-13 | — | — | WO | disclosed |
| US-4605615-A | CULTURING STREPTOMYCES | TOYO JOZO KABUSHIKI KAISHA (JP) | 1986-08-12 | — | — | US | disclosed |