Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 7/20 | 0.56 |
| ▸ | SNCA | P37840 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712587 | 0.91 | HDAC1 (0.70) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL8388266 | 0.87 | BACE1 (0.74) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL7712177 | 0.81 | HDAC8 (0.56) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3206211 | 0.81 | BACE1 (1.00) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3206225 | 0.81 | BACE1 (1.00) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL7712584 | 0.80 | HDAC8 (0.55) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL7712179 | 0.79 | HDAC6 (0.62) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3222973 | 0.77 | APP (0.64) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3198178 | 0.77 | BACE1 (0.73) | BACE1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL3198163 | 0.77 | BACE1 (0.73) | BACE1HDAC1HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9598364-B2 | Indolyl or indolinyl hydroxamate compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-03-21 | — | — | US | disclosed |
| US-20140364477-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2014-12-11 | — | — | US | disclosed |
| US-8846748-B2 | Indolyl or indolinyl hydroxamate compounds | TAIPEI MEDICAL UNIVERSITY (TW) | 2014-09-30 | — | — | US | disclosed |
| US-20110245315-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245315-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | IDH3A, IDH2, IDH3B | BACE1 3896/4885HDAC1 8/4885HDAC8 128/4885 |
| US-20140364477-A1 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS | IDH3A, IDH2, IDH3B | BACE1 3896/4885HDAC1 8/4885HDAC8 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.