Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709234 | 0.85 | TRPV1 (0.44) | TRPV1PLAUNQO2HPGDALDH1A1 | |
| SCHEMBL14433303 | 0.83 | TRPV1 (0.53) | TRPV1PLAUHPGDALDH1A1KDM4E | |
| SCHEMBL6469664 | 0.81 | TRPV1 (0.46) | TRPV1PLAUNQO2HPGDALDH1A1 | |
| SCHEMBL1963401 | 0.80 | MTNR1A (0.50) | TRPV1PLAUNQO2HPGDALDH1A1 | |
| SCHEMBL7717631 | 0.80 | GAA (0.36) | NQO2HPGDALDH1A1KDM4EGLA | |
| SCHEMBL2412766 | 0.80 | POLB (0.42) | ALDH1A1GAAMAPTKMT2ABRD9 | |
| SCHEMBL487112 | 0.79 | TRPV1 (0.44) | TRPV1PLAUNQO2HPGDALDH1A1 | |
| SCHEMBL6432988 | 0.79 | NQO2 (0.47) | NQO2HPGDALDH1A1KDM4EGLA | |
| SCHEMBL2771446 | 0.79 | CYP17A1 (0.48) | RXFP1GAANPC1RAB9A | |
| SCHEMBL14134840 | 0.78 | MTNR1A (0.51) | TRPV1PLAUHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |