Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715318 | 1.00 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7949599 | 0.99 | PDE4D (0.56) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7949596 | 0.99 | PDE4D (0.56) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7387861 | 0.85 | PDE4A (0.46) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7385711 | 0.85 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7385714 | 0.85 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL6508090 | 0.83 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8567868 | 0.83 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8770460 | 0.78 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7486451 | 0.78 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0766670-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | claimed |
| WO-1995035284-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | claimed |
| EP-0766670-B1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH R&D LTD (GB) | 2002-03-27 | — | — | EP | disclosed |
| EP-0766670-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035284-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |