Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6758010 | 0.90 | PDE4A (0.51) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL6882236 | 0.87 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL6886585 | 0.81 | PDE4A (0.45) | PDE4APDE4DPDE4BPDE4CS1PR1 | |
| SCHEMBL6508090 | 0.80 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL8567868 | 0.80 | PDE4A (0.58) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7907839 | 0.79 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7715318 | 0.78 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7715317 | 0.78 | PDE4A (0.55) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL7845534 | 0.78 | PDE4A (0.56) | PDE4APDE4DPDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7949596 | 0.77 | PDE4D (0.56) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931066-B1 | METHOD OF PREPARING PHOSPHODIESTERASE IV INHIBITORS | MERCK & CO INC (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-0626939-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014742-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |