Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.76 |
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.76 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.65 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.64 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7460325 | 0.90 | CYSLTR1 (0.67) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10547998 | 0.86 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL6583310 | 0.85 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10547475 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL4159309 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10543657 | 0.84 | CYSLTR1 (0.87) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10690965 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL1694951 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10547699 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL8098339 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0424722-A2 | Substituted (quinolin-2-yl-methoxy)phenyl-thioureas | BAYER AG (DE) | 1991-05-02 | — | — | EP | claimed |
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0424722-A2 | Substituted (quinolin-2-yl-methoxy)phenyl-thioureas | BAYER AG (DE) | 1991-05-02 | — | — | EP | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004305-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |