Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 17/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 15/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.66 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711176 | 1.00 | ADRA1A (0.66) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7714867 | 0.90 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7711289 | 0.90 | ADRA1A (0.71) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7716734 | 0.90 | ADRA1A (0.65) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7717073 | 0.90 | ADRA1A (0.65) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7716861 | 0.89 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7717168 | 0.89 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7716743 | 0.88 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7711229 | 0.88 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BMCHR1DRD2 | |
| SCHEMBL7714994 | 0.88 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BMCHR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376503-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC | 2002-04-23 | — | — | US | disclosed |
| EP-1023068-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1023068-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| WO-1998057638-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |