Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.63 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.57 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.49 |
| ▸ | F2 | P00734 | 3/20 | 0.49 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.49 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.49 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | S100B | P04271 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8994959 | 0.89 | LTB4R (0.73) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL8589819 | 0.89 | LTB4R (0.64) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8594024 | 0.88 | LTB4R (0.63) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL8593207 | 0.88 | LTB4R (0.63) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8590611 | 0.88 | LTB4R (0.63) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL8589826 | 0.87 | LTB4R (0.64) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8592018 | 0.87 | LTB4R (0.62) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL9189640 | 0.87 | LTB4R (0.64) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL9190239 | 0.86 | LTB4R (0.63) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL8590303 | 0.86 | LTB4R (0.61) | LTB4RLTB4R2PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380259-B2 | SUCH AS CHRONIC BRONCHITIS, COMPOUNDS SUCH AS 4-(5-(4-(AMINOIMINOMETHYL)PHENOXY)PENTOXY)-2-HYDROXY-N,N-BIS-( 1-METHYLETHYL)BENZAMIDE (Z)-2-BUTENEDIOATE | NOVARTIS AG (CH) | 2002-04-30 | — | — | US | disclosed |
| US-20010000341-A1 | Use of substituted amidino compounds in the treatment of chronic obstructive pulmonary disease | NOVARTIS AG (CH) | 2001-04-19 | — | — | US | disclosed |
| EP-1037617-A1 | SUBSTITUTED AMIDINO COMPOUNDS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | Novartis AG (CH) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999030695-A1 | SUBSTITUTED AMIDINO COMPOUNDS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | NOVARTIS AG (CH) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000341-A1 | Use of substituted amidino compounds in the treatment of chronic obstructive pulmonary disease | HRH4, CBR1, ACOX1 | LTB4R 159/4885LTB4R2 252/4885PRMT1 910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.