Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 11/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2584154 | 0.83 | HDAC4 (0.50) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL7708403 | 0.78 | GSK3B (0.43) | KDRCLK4ROCK1PIM1MEN1 | |
| SCHEMBL30775234 | 0.75 | CDK5 (0.51) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL9475835 | 0.73 | CDK5 (0.56) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL30825444 | 0.73 | CDK5 (0.56) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL2591611 | 0.72 | HDAC4 (0.39) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL2591838 | 0.70 | HDAC4 (0.37) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL2583621 | 0.70 | HDAC4 (0.37) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL2595302 | 0.70 | HDAC4 (0.41) | PIK3CDPIK3CAPIK3CBKDRCLK4 | |
| SCHEMBL2584315 | 0.69 | HDAC4 (0.37) | PIK3CDPIK3CAPIK3CBKDRCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |