Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679018 | 0.95 | ESR1 (0.64) | ESR1ESR2LMNAHSD17B10MIF | |
| SCHEMBL1476384 | 0.85 | L3MBTL1 (0.57) | ESR1ESR2LMNATDP1L3MBTL1 | |
| SCHEMBL11117708 | 0.85 | ESR1 (0.52) | ESR1ESR2LMNAHSD17B10CYP1A2 | |
| SCHEMBL2295719 | 0.84 | ESR1 (0.50) | ESR1ESR2LMNACYP1A2CYP3A4 | |
| SCHEMBL7629387 | 0.84 | L3MBTL1 (0.61) | ESR1ESR2LMNAMAPTCYP2C9 | |
| SCHEMBL8912131 | 0.84 | ESR1 (0.68) | ESR1ESR2MIFALOX15TDP1 | |
| SCHEMBL8914122 | 0.84 | ESR1 (0.68) | ESR1ESR2LMNAHSD17B10MIF | |
| SCHEMBL14340687 | 0.84 | ESR1 (0.58) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL6046251 | 0.84 | ESR1 (0.50) | ESR1ESR2LMNAMAPTPTGS1 | |
| SCHEMBL13687168 | 0.84 | ESR1 (0.50) | ESR1ESR2LMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113912547-B | Substituted benzene imidazole derivative and application thereof | 成都凡诺西生物医药科技有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-113912547-A | Substituted benzimidazole derivative and application thereof | 成都凡诺西生物医药科技有限公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-103159674-A | 2-benzene alkyl amid compound and preparation method, medical composition and use thereof | SUZHOU ANNUO BIOLOG MEDICAL TECHNOLOGY CO LTD | 2013-06-19 | — | — | CN | disclosed |
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4761420-A | CARDIOVASCULAR DISORDERS | LABORATOIRES SYNTEX S.A. (FR) | 1988-08-02 | — | — | US | disclosed |
| EP-0249245-A2 | Antihypertensive dihydropyridine derivatives | LABORATOIRES SYNTEX S.A. (FR) | 1987-12-16 | — | — | EP | disclosed |