Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 12/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | MDH2 | P40926 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29779535 | 0.92 | CRBN (0.58) | GAACRBNALDH1A1LMNASMYD3 | |
| SCHEMBL688478 | 0.92 | CRBN (0.58) | GAACRBNALDH1A1LMNASMYD3 | |
| SCHEMBL1459491 | 0.81 | TDP2 (0.62) | GAAEPHX2CCNB2CDK1CCNB1 | |
| SCHEMBL1359221 | 0.80 | CRBN (0.59) | GAACRBNALDH1A1LMNASMYD3 | |
| SCHEMBL29374811 | 0.80 | CRBN (0.59) | GAACRBNALDH1A1LMNASMYD3 | |
| SCHEMBL6646602 | 0.79 | CRBN (0.76) | CRBNALDH1A1LMNASMYD3HDAC3 | |
| SCHEMBL16180053 | 0.78 | SMYD3 (0.52) | GAACRBNSMYD3HDAC3EPHX2 | |
| SCHEMBL18189494 | 0.78 | GRIA1 (0.60) | GAACRBNALDH1A1LMNASMYD3 | |
| Formic Acid SCHEMBL30925701 | 0.77 | TDP2 (0.54) | GAASMYD3HDAC3EPHX2CCNB2 | |
| SCHEMBL4405727 | 0.77 | CRBN (0.65) | GAACRBNSMYD3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233943-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | Sugen, Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001037820-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | SUGEN, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |