Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823097 | 0.89 | — | — | |
| SCHEMBL6323 | 0.89 | — | — | |
| SCHEMBL8157971 | 0.89 | TSHR (0.50) | — | |
| SCHEMBL891350 | 0.89 | TSHR (0.50) | — | |
| SCHEMBL8370114 | 0.84 | — | — | |
| SCHEMBL3359261 | 0.84 | — | — | |
| SCHEMBL8740561 | 0.84 | — | — | |
| SCHEMBL20920815 | 0.84 | — | — | |
| Water SCHEMBL21456892 | 0.84 | — | — | |
| SCHEMBL8049987 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020191265-A1 | METHODS FOR TREATING PULMONARY FIBROSIS | DAVID WEINSTEIN CONSULTING, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
| US-10709686-B2 | Methods for treating pulmonary fibrosis | DAVID WEINSTEIN CONSULTING, INC. (US) | 2020-07-14 | — | — | US | disclosed |
| US-20190290612-A1 | METHODS FOR TREATING PULMONARY FIBROSIS | DAVID WEINSTEIN CONSULTING INC (US) | 2019-09-26 | — | — | US | disclosed |
| EP-3432987-A1 | METHODS FOR WOUND HEALING AND SCAR PREVENTION | Weinstein, David (US) | 2019-01-30 | — | — | EP | disclosed |
| US-20180140576-A1 | METHODS FOR WOUND HEALING AND SCAR PREVENTION | DAVID WEINSTEIN CONSULTING INC (US) | 2018-05-24 | — | — | US | disclosed |
| WO-2017165119-A1 | METHODS FOR WOUND HEALING AND SCAR PREVENTION | WEINSTEIN DAVID (US) | 2017-09-28 | — | — | WO | disclosed |
| US-20170266157-A1 | METHODS FOR WOUND HEALING AND SCAR PREVENTION | DAVID WEINSTEIN CONSULTING, INC. | 2017-09-21 | — | — | US | disclosed |
| US-6387881-B1 | PEPTIDE | TRIGEN LTD (GB) | 2002-05-14 | — | — | US | disclosed |
| EP-0509080-B1 | INHIBITORS AND SUBSTRATES OF THROMBIN | TRIGEN LTD (GB) | 2000-08-16 | — | — | EP | disclosed |
| EP-0955309-A1 | Inhibitors and substrates of thrombin | TRIGEN LIMITED (GB) | 1999-11-10 | — | — | EP | disclosed |
| US-5858979-A | ANTICOAGULANT PEPTIDES | TRIGEN LIMITED (GB) | 1999-01-12 | — | — | US | disclosed |
| EP-0807638-A1 | Inhibitors and substrates of thrombin | THROMBOSIS RESEARCH INSTITUTE (GB) | 1997-11-19 | — | — | EP | disclosed |
| US-5648338-A | PEPTIDE ANTICOAGULANT | THROMBOSIS RESEARCH INSTITUTE (GB) | 1997-07-15 | — | — | US | disclosed |
| EP-0509080-A1 | INHIBITORS AND SUBSTRATES OF THROMBIN | ELLERMAN PHARMACEUTICALS LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992007869-A1 | INHIBITORS AND SUBSTRATES OF THROMBIN | THROMBOSIS RESEARCH INSTITUTE (GB) | 1992-05-14 | — | — | WO | disclosed |