Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712168 | 0.83 | KMT2A (0.51) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL937306 | 0.82 | NPC1 (0.44) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL18985894 | 0.82 | CYP1A2 (0.43) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL7712166 | 0.80 | S1PR1 (0.44) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| Hydrochloric Acid SCHEMBL27685777 | 0.80 | CYP1A2 (0.42) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL807736 | 0.78 | CYP1A2 (0.41) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL12051579 | 0.78 | ELOVL1 (0.50) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL14421262 | 0.78 | JAK3 (0.57) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL2041732 | 0.77 | CYP1A2 (0.41) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL12705674 | 0.77 | JAK3 (0.40) | CYP1A2CYP2D6ALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380263-B1 | ADMINISTERING TO HUMAN EFFECTIVE TYROSINASE ACTIVITY-STIMULATING AMOUNT OF AT LEAST ONE 6-SUBSTITUTED PYRIMIDINE 3-OXIDE COMPOUND FOR PROMOTING PIGMENTATION OF THE SKIN AND/OR HAIR | SOCIETE L'OREAL (FR) | 2002-04-30 | — | — | US | disclosed |