SCHEMBL7717816

SCHEMBL7717816

CC(C)(C)[Si](Oc1cccc2c1CCC(O)C(O)(COC(=O)N(c1ccccc1)c1ccccc1)C2)(c1ccccc1)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 16/20 0.49
PTGDR Q13258 8/20 0.49
PTGER3 P43115 2/20 0.49
PTGER1 P34995 1/20 0.49
CHRM4 P08173 1/20 0.34
CHRM5 P08912 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
ACHE P22303 1/20 0.31
PTGER4 P35408 1/20 0.30
PTGER2 P43116 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776620 0.85 PTGIR (0.67) PTGIRPTGDRPTGER3PTGER1CHRM4
SCHEMBL7778395 0.85 PTGIR (0.67) PTGIRPTGDRPTGER3PTGER1CHRM4
SCHEMBL7717833 0.82 PTGIR (0.71) PTGIRPTGDRPTGER3PTGER1
SCHEMBL7716647 0.81 PTGIR (0.50) PTGIRPTGDRPTGER3PTGER1CHRM4
SCHEMBL7776652 0.81 PTGIR (0.66) PTGIRPTGDRPTGER3PTGER1PTGER4
SCHEMBL8481589 0.81 PTGIR (0.56) PTGIRPTGDRPTGER3PTGER1CHRM4
SCHEMBL7720284 0.81 PTGIR (0.61) PTGIRPTGDRPTGER3PTGER1
SCHEMBL7777381 0.81 PTGIR (0.39) PTGIRPTGDRPTGER3PTGER1CHRM4
SCHEMBL7718288 0.80 PTGIR (0.51) PTGIRPTGDRPTGER3PTGER1CHRM4
SCHEMBL7052348 0.80 PTGIR (0.61) PTGIRPTGDRPTGER3PTGER1PTGER4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6384072-B1 CARBAMYL SUBSTITUTED COMPOUNDS WITH ETHER GROUPS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-05-07 US disclosed