Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 13/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.73 |
| ▸ | PGR | P06401 | 2/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.62 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | GC | P02774 | 1/20 | 0.59 |
| ▸ | RXRA | P19793 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7715724 | 1.00 | VDR (0.75) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL7714471 | 0.92 | VDR (0.77) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL7718712 | 0.92 | VDR (0.77) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL12749728 | 0.92 | VDR (0.77) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL8529871 | 0.92 | VDR (0.77) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL7716289 | 0.92 | VDR (0.77) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL7716477 | 0.92 | VDR (0.77) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL8584234 | 0.90 | VDR (0.81) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL8189116 | 0.90 | VDR (0.74) | VDRADORA3SLC6A2NR1I2PGR | |
| SCHEMBL7710877 | 0.90 | VDR (0.74) | VDRADORA3SLC6A2NR1I2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832063-B1 | VITAMIN D DERIVATIVES WITH C-25 SUBSTITUENTS, PROCESS FOR THEIR PREPARATION, INTERMEDIATE PRODUCTS AND THEIR USE IN PREPARING MEDICAMENTS | SCHERING AG (DE) | 2000-02-23 | — | — | EP | claimed |
| US-6376480-B1 | TREATMENT OF IMMUNE SYSTEM DISORDERS, OSTEOPOROSIS, ALOPECIA | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-23 | — | — | US | disclosed |