Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 5/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.43 |
| ▸ | PDE2A | O00408 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 6/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324162 | 0.92 | PDE3B (0.46) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL7719683 | 0.88 | PDE2A (0.40) | PDE2A | |
| SCHEMBL2213264 | 0.85 | ALDH1A1 (0.48) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2327181 | 0.84 | PPARG (0.52) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2213928 | 0.84 | PDE3B (0.45) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL6618987 | 0.84 | PDE3B (0.45) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2213642 | 0.83 | PDE3B (0.46) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2213545 | 0.82 | PPARG (0.46) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL2329776 | 0.82 | SIRT2 (0.51) | PDE3BPDE3APDE2APPARGPPARA | |
| SCHEMBL6582267 | 0.82 | PDE3B (0.48) | PDE3BPDE3APDE2APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | claimed |