Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | FDPS | P14324 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320092 | 0.89 | HSD17B2 (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6401723 | 0.88 | HSD17B2 (0.61) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL4376688 | 0.87 | MAPT (0.59) | SMN1; SMN2TSHRMAPTMAPK1KMT2A | |
| SCHEMBL29171428 | 0.86 | THRA (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL11342699 | 0.86 | POLB (0.53) | HSD17B2TSHRMAPK1LMNAPOLB | |
| SCHEMBL29171425 | 0.86 | THRA (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL31474383 | 0.86 | THRA (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL2308139 | 0.86 | THRA (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL11245624 | 0.86 | THRA (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL29171436 | 0.86 | THRA (0.62) | HSD17B2NPC1RAB9ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |