Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 17/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7714409 | 1.00 | VDR (0.52) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7718761 | 1.00 | VDR (0.52) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7714441 | 1.00 | VDR (0.52) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7716469 | 1.00 | VDR (0.52) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7714527 | 1.00 | VDR (0.52) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7717016 | 0.99 | VDR (0.53) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7716791 | 0.99 | VDR (0.53) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7710884 | 0.97 | VDR (0.53) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL8706754 | 0.97 | VDR (0.53) | VDRHDAC3HDAC6HDAC2NR1I2 | |
| SCHEMBL7714406 | 0.97 | VDR (0.53) | VDRHDAC3HDAC6HDAC2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376480-B1 | TREATMENT OF IMMUNE SYSTEM DISORDERS, OSTEOPOROSIS, ALOPECIA | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-23 | — | — | US | disclosed |
| US-6372731-B1 | TREATMENT OF CELL PROLIFERATION AND BONE DISORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-16 | — | — | US | disclosed |
| EP-0832063-B1 | VITAMIN D DERIVATIVES WITH C-25 SUBSTITUENTS, PROCESS FOR THEIR PREPARATION, INTERMEDIATE PRODUCTS AND THEIR USE IN PREPARING MEDICAMENTS | SCHERING AG (DE) | 2000-02-23 | — | — | EP | disclosed |