Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685240 | 0.75 | ATM (0.36) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL949982 | 0.74 | KCNA5 (0.46) | GAAKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8507646 | 0.74 | ATM (0.37) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL12694263 | 0.72 | RAB9A (0.41) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL294332 | 0.72 | RAB9A (0.41) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL13104826 | 0.72 | RAB9A (0.41) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL10115951 | 0.72 | RAB9A (0.41) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL9992063 | 0.71 | ATM (0.36) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL20774847 | 0.71 | ATM (0.36) | ATMGAATHRBRAB9AKMT2A | |
| SCHEMBL7718578 | 0.71 | ATM (0.36) | ATMGAATHRBRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |